2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

Related Products

PDF 32.36 MB

Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-17352R
    Clazosentan (Standard) 180384-56-9 98%
    Clazosentan (Standard) is the analytical standard of Clazosentan. This product is intended for research and analytical applications. Clazosentan (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction.
    Clazosentan (Standard)
  • HY-17369R
    Tirofiban hydrochloride monohydrate (Standard) 150915-40-5 98%
    Tirofiban (hydrochloride monohydrate) (Standard) is the analytical standard of Tirofiban (hydrochloride monohydrate). This product is intended for research and analytical applications. Tirofiban (L700462) hydrochloride monohydrate is a selective and reversible platelet integrin receptor (Gp IIb/IIIa) antagonist that inhibits fibrinogen binding to this receptor and has antithrombotic activity. Tirofiban hydrochloride monohydrate induces proliferation and migration on endothelial cell by inducing production of VEGF. Tirofiban hydrochloride monohydrate can significantly reduces myocardial no-reflow and ischemia-reperfusion injury by alleviating myocardial microvascular structural and endothelial dysfunction in the ischemic area.
    Tirofiban hydrochloride monohydrate (Standard)
  • HY-17401R
    Ranolazine dihydrochloride (Standard) 95635-56-6 98%
    Ranolazine (dihydrochloride) (Standard) is the analytical standard of Ranolazine (dihydrochloride). This product is intended for research and analytical applications. Ranolazine dihydrochloride (CVT 303 dihydrochloride) is an anti-angina agent that achieves its effects by inhibiting the late phase of inward sodium current (INa and IKr with IC50 values of 6 μM and 12 μM, respectively) without affecting heart rate or blood pressure (BP). Ranolazine dihydrochloride is also a partial fatty acid oxidation inhibitor.
    Ranolazine dihydrochloride (Standard)
  • HY-17403R
    Manidipine dihydrochloride (Standard) 89226-75-5 98%
    Manidipine (dihydrochloride) (Standard) is the analytical standard of Manidipine (dihydrochloride). This product is intended for research and analytical applications. Manidipine dihydrochloride is a third-generation, lipophilic, orally active and highly vasoselective calcium channel antagonist (IC50 = 2.6 nM in guinea-pig ventricular cells) and acts as an antihypertensive agent. Manidipine effectively reduces blood pressure as well as improving insulin sensitivity, renal protection, and antiatherosclerotic activity. Manidipine also exerts anti-inflammatory activity mediated by NF-κB and antiviral activity against many flavivirus and negative-strand RNA viruses through the inhibition of calcium channel. Manidipine is widely applied to research of cardiovascular, metabolic disease and infection.
    Manidipine dihydrochloride (Standard)
  • HY-17404R
    Cilnidipine (Standard) 132203-70-4 98%
    Cilnidipine (Standard) is the analytical standard of Cilnidipine. This product is intended for research and analytical applications. Cilnidipine is a long-acting, second-generation dihydropyridine Ca2+-channel blocker on L and N-type Ca2+ channel. Antihypertensive effects.
    Cilnidipine (Standard)
  • HY-17416R
    Guanfacine hydrochloride (Standard) 29110-48-3 99.95%
    Guanfacine (hydrochloride) (Standard) is the analytical standard of Guanfacine (hydrochloride). This product is intended for research and analytical applications. Guanfacine hydrochloride is an orally active noradrenergic α2A agonist and has high selective for the α2A receptor subtype. Guanfacine has effects in producing hypotension and sedation. Guanfacine can be used for the research of a variety of prefrontal cortex (PFC) cognitive disorders, including tourette's syndrome and attention deficit hyperactivity disorder (ADHD).
    Guanfacine hydrochloride (Standard)
  • HY-174256
    GRL-098-22
    GRL-098-22 (Compound 6t) is a potent inhibitor targeting G protein-coupled receptor kinase 5 (GRK5) and GRK6 with IC50 values of 0.6 μM and 0.19 μM, respectively. GRL-098-22 is promising for research of diseases such as heart failure and multiple myeloma.
    GRL-098-22
  • HY-17429R
    Flecainide acetate (Standard) 54143-56-5 98%
    Flecainide (acetate) (Standard) is the analytical standard of Flecainide (acetate). This product is intended for research and analytical applications. Flecainide acetate (R-818) is a class 1C antiarrhythmic agent especially used for the management of supraventricular arrhythmia; works by blocking the Nav1.5 sodium channel in the heart, causing prolongation of the cardiac action potential.
    Flecainide acetate (Standard)
  • HY-174333
    CYP1A1-IN-1 3065926-17-9
    CYP1A1-IN-1 (Compound 47) is a small-molecule cytochrome P4501A1 (CYP1A1) inhibitor. CYP1A1-IN-1 reduces the bacterial loads of methicillin-resistant Staphylococcus aureus (MRSA) and Acinetobacter baumannii by enhancing macrophage phagocytosis. CYP1A1-IN-1 is promising for research of sepsis caused by multidrug-resistant (MDR) bacteria.
    CYP1A1-IN-1
  • HY-174334
    RXFP1 receptor agonist-9 2924765-23-9 98%
    RXFP1 receptor agonist-9 is a potent RXFP1 agonist with an EC50 of 2.5 μM and Ymax of 65%. RXFP1 receptor agonist-9 exhibits good microsomal stability, reasonable PK and pharmacological activity. RXFP1 receptor agonist-9 can be used to the study of heart failure.
    RXFP1 receptor agonist-9
  • HY-17436R
    Clevidipine (Standard) 167221-71-8 98%
    Clevidipine (Standard) is the analytical standard of Clevidipine. This product is intended for research and analytical applications. Clevidipine is a short-acting dihydropyridine calcium channel antagonist (IC50= 7.1 nM, V(H) = -40 mV ).
    Clevidipine (Standard)
  • HY-174477
    Mouse Tbx5 mRNA 98%
    Mouse Tbx5 mRNA encodes the mouse T-box 5 (Tbx5) protein, a DNA-binding protein that regulates the transcription of several genes. Tbx5 is involved in heart development and limb pattern formation.
    Mouse Tbx5 mRNA
  • HY-174479
    Mouse Mef2c mRNA 98%
    Mouse Mef2c mRNA encodes the mouse myocyte enhancer factor 2C (Mef2c) protein, a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Mef2c controls cardiac morphogenesis and myogenesis, and is also involved in vascular development, neurogenesis and the development of cortical architecture.
    Mouse Mef2c mRNA
  • HY-174480
    Mouse Hand2 mRNA 98%
    Mouse Hand2 mRNA encodes the mouse heart and neural crest derivatives expressed 2 (Hand2) protein, which is essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries.
    Mouse Hand2 mRNA
  • HY-174481
    Mouse Gata4 mRNA 98%
    Mouse Gata4 mRNA encodes the mouse GATA binding protein 4 (Gata4) protein, a transcriptional activator that binds to the consensus sequence 5''-AGATAG-3'' and plays a key role in cardiac development.
    Mouse Gata4 mRNA
  • HY-174538
    Human TBX5 mRNA 98%
    Human TBX5 mRNA encodes the human T-box transcription factor 5 (TBX5) protein, a member of a phylogenetically conserved family. TBX5 is a DNA-binding protein that regulates the transcription of several genes and also involved in heart development and limb pattern formation.
    Human TBX5 mRNA
  • HY-174582
    Human MESP1 mRNA 98%
    Human MESP1 mRNA encodes the human Mesoderm posterior bHLH transcription factor 1 (MESP1) protein, a member of transcription factor which plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm.
    Human MESP1 mRNA
  • HY-17458R
    Azilsartan medoxomil monopotassium (Standard) 863031-24-7
    Azilsartan medoxomil monopotassium (Standard) is the analytical standard of Azilsartan medoxomil monopotassium (HY-17458V). This product is intended for research and analytical applications. Azilsartan medoxomil (TAK 491) monopotassium, a prodrug form of Azilsartan (HY-14914), is an orally active angiotensin II receptor type 1 antagonist. Azilsartan medoxomil monopotassium can be used for the study of essential hypertension.
    Azilsartan medoxomil monopotassium (Standard)
  • HY-17464R
    Cilostazol (Standard) 73963-72-1 98%
    Cilostazol (Standard) is the analytical standard of Cilostazol. This product is intended for research and analytical applications. Cilostazol (OPC 13013) is a potent and selective inhibitor of phosphodiesterase (PDE) 3A, the isoform of PDE 3 in the cardiovascular system, with an IC50 of 0.2 μM.
    Cilostazol (Standard)
  • HY-174671
    Human HBEGF mRNA 98%
    Human HBEGF mRNA encodes the human heparin binding EGF like growth factor (HBEGF) protein, a growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. HBEGF may be involved in normal cardiac valve formation and normal heart function.
    Human HBEGF mRNA
Cat. No. Product Name / Synonyms Application Reactivity